Elements of Comet III. 1857

Dmd059097 1851..1857

Solute carrier (SLC) transporters regulate the cellular influx and disposition of endogenous and xenobiotic compounds, including anticancer agents such as the multikinase inhibitors (MKIs). Recent evidence suggests that MKIs may also inhibit SLC-dependent transport of coadministered drugs, although present information on the relative susceptibilities of multiple SLC transporters is limited. Thi...

Paul Eugen Bleuler (1857?1939)

Paul Eugen Bleuler studied autism and schizophrenia, among other psychiatric disorders, throughout continental Europe in the early twentieth century. Bleuler worked as a psychiatrist caring for patients with psychiatric disorders at a variety of facilities in Europe. In 1908, Bleuler coined the term schizophrenia to describe a group of diseases that cause changes in thought processes and behavi...

Dev104224 1857..1863

TheCXCL12/CXCR4 signaling pathway is involved in the development of numerous neuronal and non-neuronal structures. Recent work established that the atypical second CXCL12 receptor, CXCR7, is essential for the proper migration of interneuron precursors in the developing cerebral cortex. Two CXCR7-mediated functions were proposed in this process: direct modulation of β-arrestin-mediated signaling...

[Sir Robert Jones (1857-1933)].

Julius Wagner-Jauregg (1857–1940)

Apart from the author's specific observations, two broader themes seem to emerge. First, the modem medical fatwais demonstrate a clear continuity from medieval times. Companions of the prophet Muhammad and classical legal compendia are cited as easily-and as cogently-in the twentieth century as in the tenth, the mode of argument is often identical, and the classical terminology of classical Isl...